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Normal Reactions: Variants

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Click here to Zoom Secondary vaccinia lesion adjacent to primary site
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Normal Variant: Satellite Lesions


Click here to Zoom Large, edematous and erythematous plaque with lymphangitis
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Normal Variant: Lymphangitis


Click here to Zoom Edematous and erythematous 7cm area surrounding vaccination pustule
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Normal Variant: Edema


Click here to Zoom Normal Variant, lesion with viral cellulitis
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Normal Variant: Viral Cellulitis


Variations of normal reactions that are not considered adverse events can include:

•  Local satellite lesions(*)
(that are normal in appearance)
•  Lymphangitis
•  Local edema
•  Robust take ()
(intense inflammation surrounding the papule)

* The frequency of satellite lesions varies from study to study (2.4 to 6.6 %).
This normal consequence of vaccination is a viral cellulitis at the vaccination site of varying degree that peaks at about 7-10 days following vaccination. A robust take or larger amount of inflammation surrounding the site, is often confused with bacterial infection

Management

None of these expected variations of normal reactions require any treatment other than symptomatic relief.

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